JAMACardiology
BriefReport
AssociationofaNovelDiagnosticBiomarker,thePlasmaCardiacBridgingIntegrator1Score,
WithHeartFailureWithPreservedEjectionFractionandCardiovascularHospitalization
AndrianaP.Nikolova,MD;TaraC.Hitzeman,MPH;RachelBaum,BS;Ana-MariaCaldaruse,BS;SosseAgvanian,BS;YuXie,MD;DaelR.Geft,MD;DavidH.Chang,MD;JaimeD.Moriguchi,MD;AntoineHage,MD;BabakAzarbal,MD;LawrenceS.Czer,MD;MichelleM.Kittleson,MD,PhD;JigneshK.Patel,MD,PhD;AlanH.B.Wu,PhD;JonA.Kobashigawa,MD;MicheleHamilton,MD;TingTingHong,MD,PhD;RobinM.Shaw,MD,PhD
IMPORTANCETransversetubuleremodelingisahallmarkofheartfailure.Cardiacbridgingintegrator1(cBIN1)isacirculatingmembranescaffoldingproteinthatisessentialfortransversetubulehealth,anditsplasmaleveldeclineswithdisease.
EditorsNoteSupplementalcontent
OBJECTIVETodetermineifacBIN1-derivedscorecanserveasadiagnosticbiomarkerofheartfailurewithpreservedejectionfraction(HFpEF).
DESIGN,SETTING,ANDPARTICIPANTSInthiscohortstudy,thecBIN1score(CS)wasdeterminedfromenzyme-linkedimmunoabsorbentassay–measuredplasmacBIN1concentrationsfromstudyparticipantsinanambulatoryheartfailureclinicatCedars-SinaiMedicalCenter.Consecutivepatientswithaconfirmeddiagnosisofheartfailurewithpreservedejectionfraction(HFpEF;definedbyaleftventricularejectionfraction?50%)wererecruitedfromJulytoNovemberand
