Some5.8millionAmericanssufferfromheartfailure,acurrentlyincurable1disease.ButscientistsatTempleUniversitySchoolofMedicines(TUSM)CenterforTranslationalMedicinehavediscoveredakeybiochemicalstepunderlying2theconditionthatcouldaidthedevelopmentofnewdrugstotreatandpossiblypreventit.Drugswecurrentlyuseforheartfailurearenotveryeffective,explainedleadinvestigator3WalterJ.Koch,PhD,ProfessorandChairmanoftheDepartmentofPharmacologyatTUSM,andDirectoroftheCenterforTranslationalMedicineatTUSM.But,headded,Themorewelearnaboutthediseasemechanism4,themoredrugtargetswellfind.
ThatiswhatKochandcolleaguesatThomasJeffersonUniversityandtheUniversityofCalifornia,Davis,achievedintheirlateststudy,whichappearsintheMarch5issueoftheonlinejournalPLOSONE.Thereportisthefirsttoshowthatanenzyme5calledGRK5(G-proteincoupledreceptorkinase5)cangainaccesstoaheartcellsnucleus6--its南京白癜风医院北京白癜风医院哪里好
